This is a big area transversed by I-84 and numerous U.S. Highways. Most off-the-beaten-path attractions which most are must be accessed by the many scenic roads running through the high plains and mountains of the area. Private vehicle is practically the only way to travel in the area, but cycling could be enjoyable and physically demanding on many of the smaller highways.
U.S. Route 26 is located in the northern part of Eastern Oregon and runs from the coast to the Idaho border.
U.S. Route 20 travels east-west through the center and south part of the state, providing access to Burns and its attractions until it crosses into Idaho.
U.S. Route 395 makes its way roughly NNE through Oregon and passes from the OR-CA state line to Idaho, passing through Lakeview, Riley, and John Day on its way.
